2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126179R
    Fenquizone (Standard) 20287-37-0 98%
    Fenquizone (MG-13054) (Standard) is the analytical standard of Fenquizone (HY-126179). This product is intended for research and analytical applications. Fenquizone is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics.​ Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension.
    Fenquizone (Standard)
  • HY-126358R
    Acetylcarnitine (Standard) 14992-62-2 98%
    Acetylcarnitine (Standard) is the analytical standard of Acetylcarnitine. This product is intended for research and analytical applications. Acetylcarnitine is an endogenous metabolite.
    Acetylcarnitine (Standard)
  • HY-126358S
    Acetylcarnitine-d3 204259-54-1
    Acetylcarnitine-d3 is the deuterium labeled Acetylcarnitine (HY-126358). Acetylcarnitine is an endogenous metabolite.
    Acetylcarnitine-d3
  • HY-126410R
    Petunidin chloride (Standard) 1429-30-7
    Petunidin (chloride) (Standard) is the analytical standard of Petunidin (chloride). This product is intended for research and analytical applications. Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.
    Petunidin chloride (Standard)
  • HY-12642AR
    Diethylcarbamazine (Standard) 90-89-1 98%
    Diethylcarbamazine (Standard) is the analytical standard of Diethylcarbamazine (HY-12642A). This product is intended for research and analytical applications. Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection.
    Diethylcarbamazine (Standard)
  • HY-126488R
    H-Ser-His-OH (Standard) 67726-09-4 98%
    H-Ser-His-OH (Standard) is the analytical standard of H-Ser-His-OH. This product is intended for research and analytical applications. H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite.
    H-Ser-His-OH (Standard)
  • HY-126855S
    Cholic acid 7-sulfate-d4 1332881-66-9
    Cholic acid 7-sulfate-d4 (7-Sulfocholic acid-d4) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.
    Cholic acid 7-sulfate-d4
  • HY-127127A
    Deamino-NAD sodium 104809-38-3 98%
    Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a Km of 2300 pm, and a Kd of 112 pm.
    Deamino-NAD sodium
  • HY-12717AR
    Phentolamine hydrochloride (Standard) 73-05-2 98%
    Phentolamine (hydrochloride) (Standard) is the analytical standard of Phentolamine (hydrochloride). This product is intended for research and analytical applications. Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent.
    Phentolamine hydrochloride (Standard)
  • HY-12756AR
    E6446 dihydrochloride (Standard) 1345675-25-3 98%
    E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).
    E6446 dihydrochloride (Standard)
  • HY-128400R
    4'-Methoxychalcone (Standard) 959-23-9 98%
    4'-Methoxychalcone (Standard) is the analytical standard of 4'-Methoxychalcone. This product is intended for research and analytical applications. 4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
    4'-Methoxychalcone (Standard)
  • HY-128442R
    Phenyl sulfate (Standard) 937-34-8 98%
    Phenyl sulfate (Standard) is the analytical standard of Phenyl sulfate. This product is intended for research and analytical applications. Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease.
    Phenyl sulfate (Standard)
  • HY-128720R
    Diethyl oxalpropionate (Standard) 759-65-9
    Diethyl oxalpropionate (Standard) is the analytical standard of Diethyl oxalpropionate. This product is intended for research and analytical applications. Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.
    Diethyl oxalpropionate (Standard)
  • HY-128735R
    N-Formylglycine (Standard) 2491-15-8 98%
    N-Formylglycine (Standard) is the analytical standard of N-Formylglycine. This product is intended for research and analytical applications. N-Formylglycine is an endogenous metabolite.
    N-Formylglycine (Standard)
  • HY-128739R
    Isomaltulose hydrate (Standard) 343336-76-5 98%
    Isomaltulose (hydrate) (Standard) is the analytical standard of Isomaltulose (hydrate). This product is intended for research and analytical applications. Isomaltulose hydrate is an endogenous metabolite.
    Isomaltulose hydrate (Standard)
  • HY-128854R
    Dimethyl biphenyl-4,4'-dicarboxylate (Standard) 792-74-5
    Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) (Standard) is the analytical standard of Dimethyl biphenyl-4,4'-dicarboxylate. This product is intended for research and analytical applications. Dimethyl biphenyl-4,4'-dicarboxylate is a hepatoprotectant that can be obtained from Schizandra fructus and may induce a signal transduction similar to that associated with IFN. Dimethyl biphenyl-4,4'-dicarboxylate can be synthesized from bio-derived 4,4’-Dimethylbiphenyl.
    Dimethyl biphenyl-4,4'-dicarboxylate (Standard)
  • HY-128878R
    Dexloxiglumide (Standard) 119817-90-2 98%
    Dexloxiglumide (Standard) is the analytical standard of Dexloxiglumide. This product is intended for research and analytical applications. Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors.
    Dexloxiglumide (Standard)
  • HY-129440R
    N-(p-Coumaroyl) Serotonin (Standard) 68573-24-0 98%
    N-(p-Coumaroyl) Serotonin (Standard) is the analytical standard of N-(p-Coumaroyl) Serotonin (HY-129440). This product is intended for research and analytical applications. N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
    N-(p-Coumaroyl) Serotonin (Standard)
  • HY-129623R
    Ethyl nonanoate (Standard) 123-29-5
    Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator.
    Ethyl nonanoate (Standard)
  • HY-129974R
    3,3'-Diiodo-L-thyronine (Standard) 4604-41-5
    3,3'-Diiodo-L-thyronine (Standard) is the analytical standard of 3,3'-Diiodo-L-thyronine. This product is intended for research and analytical applications. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
    3,3'-Diiodo-L-thyronine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity